The EXGAVINE project aims to adapt three genres of VR motion games, in particular (i) target games, (ii) racing games, and (iii) brain games, specifically to the diverse neurological clinical pictures of patients with regard to functional, motor, cognitive and emotional abilities and limitations. Patients are to solve motor-cognitive complex tasks together in these VR movement games according to the dual-task paradigm. To this end, a combination of markerless optical tracking systems and wearables will be developed to initially record the macro and micro movements of several patients (as well as doctors and specialists for remote care), combining the advantages of both approaches. The acquisition and analysis of movement data in real time allows to use the patient’s performance to log the course of therapy, to identify changes and to adjust medical-therapeutic VR motion games adaptively. In addition, the professional staff has the possibility to provide real-time feedback on the therapy in the virtual world via reconstructed 3D avatars, even over greater distances, thus optimally complementing traditional forms of therapy. In an interdisciplinary consortium with internationally proven expertise in the areas of VR and human-computer interaction, motion detection and wearables, gamification and serious games as well as domain experts for neurological diseases, solutions are to be developed in the project and tested, examined and continuously improved in the form of a Living Lab in the everyday life of patients.